KMID : 0358420080510060682
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Korean Journal of Obstetrics and Gynecology 2008 Volume.51 No. 6 p.682 ~ p.685
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Sister Mary Joseph`s nodule from advanced ovarian carcinoma
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Kim Jeong-Sig
Kim Tae-Hee Lee Hae-Hyeog Lee Kwon-Hae Nam Kye-Hyun
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Abstract
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Umbilical metastasis may be the first presenting sign of the disease, or an indication of a recurrence from a previous malignancy. We recently encountered a 19-year-old woman with advanced ovarian adenocarcinoma whose first sign was having a Sister Mary Joseph¡¯s nodule. This patient only presented an umbilical nodule with slight lower abdominal discomfort, without any other subjective symptom. The lesion was fresh red, firm, ulcerating and has 1.5 cm in diameter. A punch biopsy from the lesion revealed metastatic adenocarcinoma and a PET-CT scan showed hypermetabolism on the umbilicus. After a systemic evaluation, she had a laparotomy including right salpingo-oophorectomy, total omentectomy, pelvic and paraaortic lymphadenectomy, appendectomy, and extirpation of the umbilicus. The patient received a postoperative combination of chemotherapy with paclitaxel and carboplatin, and still remains alive. This case demonstrates the importance of careful evaluation of any umbilical lesion and pathologic examination.
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KEYWORD
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Sister Mary Joseph`s nodule, Ovarian carcinoma, Umbilicus
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